Here is the easiest ways to remove System Preference Panes you’ve added over time and no longer need. Simply control-click, or right-click, on a preference icon in the Others section of your System Preferences (the Other section contains the custom preferences installed by users). A pop-up menu lets you remove the selected preference pane.
This is a great way for those of you who don’t want to go digging through various Library folders looking for the actual preference pane manually.
Source: This tip comes directly from James Dempsey’s terrific The Graphic Mac. Want a more advanced preferences tip? Check out Jordan Bojar’s post on how to Manage Account Preferences across your entire studio from a Mac OS X Server.